Epigenetic regulation of neuronal maturation : the effect of MeCP2 and MicroRNAs on the maturation of hippocampal neurons
نویسندگان
چکیده
OF DISSERTATION Submitted in Partial Fulfillment of the Requirements for the Degree of The University of New Mexico Albuquerque, New Mexico
منابع مشابه
Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons.
It is well known that Rett Syndrome, a severe postnatal childhood neurological disorder, is mostly caused by mutations in the MECP2 gene. However, how deficiencies in MeCP2 contribute to the neurological dysfunction of Rett Syndrome is not clear. We aimed to resolve the role of MeCP2 epigenetic regulation in postnatal brain development in an Mecp2-deficient mouse model. We found that, while Mec...
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